The regions are at the helm of the PNHRS. The PNHRS framework is mirrored in all the regions of the country, forming a network of regional health research system. The consortium set-up varies depending on the culture and resources of the region.

Each consortium involves of various institutions ranging from academe, hospital, and private and governmental organizations. It establishes linkages between the researchers and institutions as well as promotes health research activities attuned to local health needs.